Filarial glutathione-S-transferase: a potential vaccine candidate against lymphatic filariasis.
Identifieur interne : 006B11 ( Main/Exploration ); précédent : 006B10; suivant : 006B12Filarial glutathione-S-transferase: a potential vaccine candidate against lymphatic filariasis.
Auteurs : Sushma Rathaur [Inde] ; Marshleen Yadav ; Sarika Gupta ; V. Anandharaman ; Maryada Venkatarami ReddySource :
- Vaccine [ 0264-410X ] ; 2008.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiprotozoaires (sang), Brugia malayi (immunologie), Cytokines (immunologie), Femelle, Filariose lymphatique (), Filariose lymphatique (immunologie), Gerbillinae (parasitologie), Glutathione transferase (immunologie), Lymphocytes T (cytologie), Lymphocytes T (immunologie), Mâle, Prolifération cellulaire, Souris, Souris de lignée BALB C, Vaccins antiprotozoaires (immunologie).
- MESH :
- cytologie : Lymphocytes T.
- immunologie : Brugia malayi, Cytokines, Filariose lymphatique, Glutathione transferase, Lymphocytes T, Vaccins antiprotozoaires.
- parasitologie : Gerbillinae.
- sang : Anticorps antiprotozoaires.
- Animaux, Femelle, Filariose lymphatique, Mâle, Prolifération cellulaire, Souris, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Animals, Antibodies, Protozoan (blood), Brugia malayi (immunology), Cell Proliferation, Cytokines (immunology), Elephantiasis, Filarial (immunology), Elephantiasis, Filarial (prevention & control), Female, Gerbillinae (parasitology), Glutathione Transferase (immunology), Male, Mice, Mice, Inbred BALB C, Protozoan Vaccines (immunology), T-Lymphocytes (cytology), T-Lymphocytes (immunology).
- MESH :
- chemical , blood : Antibodies, Protozoan.
- cytology : T-Lymphocytes.
- immunology : Brugia malayi, Cytokines, Elephantiasis, Filarial, Glutathione Transferase, Protozoan Vaccines, T-Lymphocytes.
- parasitology : Gerbillinae.
- prevention & control : Elephantiasis, Filarial.
- Animals, Cell Proliferation, Female, Male, Mice, Mice, Inbred BALB C.
Abstract
Present report enumerates the vaccine potential of a glutathione-S-transferase purified from Setaria cervi against lymphatic filariasis. In jirds (Meriones unguiculatus) vaccination trial, a very significant 82.75% (p<0.005) reduction in adult parasite burden was observed in ScGST immunized group after 90 days post Brugia malayi L3 challenge. An inverse correlation between the antibody level and worm burden was found in ScGST immunized group (Person's correlation r=0.943, p<0.05). No recoveries of worms were obtained in heart and lungs of vaccinated group. The Antibodies reactive to ScGST appeared within four weeks of first dose and were able to neutralize the GST activity up to 86%. In an earlier study we have shown vaccine potential of ScGST against B. malayi by ADCC. Evaluation of cytokine profile in T-cells isolated from BALB/c mice immunized with ScGST were also showed predominance of Th2 response which further maintained the humoral immunity generated by ScGST administration in mice. The overall observations prompted us to envisage ScGST as a potential vaccine candidate against lymphatic filariasis.
DOI: 10.1016/j.vaccine.2008.03.099
PubMed: 18499308
Affiliations:
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Anandharaman</name></author><author><name sortKey="Reddy, Maryada Venkatarami" sort="Reddy, Maryada Venkatarami" uniqKey="Reddy M" first="Maryada Venkatarami" last="Reddy">Maryada Venkatarami Reddy</name></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Protozoan (blood)</term><term>Brugia malayi (immunology)</term><term>Cell Proliferation</term><term>Cytokines (immunology)</term><term>Elephantiasis, Filarial (immunology)</term><term>Elephantiasis, Filarial (prevention & control)</term><term>Female</term><term>Gerbillinae (parasitology)</term><term>Glutathione Transferase (immunology)</term><term>Male</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Protozoan Vaccines (immunology)</term><term>T-Lymphocytes (cytology)</term><term>T-Lymphocytes (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiprotozoaires (sang)</term><term>Brugia malayi (immunologie)</term><term>Cytokines (immunologie)</term><term>Femelle</term><term>Filariose lymphatique ()</term><term>Filariose lymphatique (immunologie)</term><term>Gerbillinae (parasitologie)</term><term>Glutathione transferase (immunologie)</term><term>Lymphocytes T (cytologie)</term><term>Lymphocytes T (immunologie)</term><term>Mâle</term><term>Prolifération cellulaire</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Vaccins antiprotozoaires (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Protozoan</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Lymphocytes T</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Brugia malayi</term><term>Cytokines</term><term>Filariose lymphatique</term><term>Glutathione transferase</term><term>Lymphocytes T</term><term>Vaccins antiprotozoaires</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brugia malayi</term><term>Cytokines</term><term>Elephantiasis, Filarial</term><term>Glutathione Transferase</term><term>Protozoan Vaccines</term><term>T-Lymphocytes</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Gerbillinae</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Gerbillinae</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiprotozoaires</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Proliferation</term><term>Female</term><term>Male</term><term>Mice</term><term>Mice, Inbred BALB C</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Femelle</term><term>Filariose lymphatique</term><term>Mâle</term><term>Prolifération cellulaire</term><term>Souris</term><term>Souris de lignée BALB C</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Present report enumerates the vaccine potential of a glutathione-S-transferase purified from Setaria cervi against lymphatic filariasis. In jirds (Meriones unguiculatus) vaccination trial, a very significant 82.75% (p<0.005) reduction in adult parasite burden was observed in ScGST immunized group after 90 days post Brugia malayi L3 challenge. An inverse correlation between the antibody level and worm burden was found in ScGST immunized group (Person's correlation r=0.943, p<0.05). No recoveries of worms were obtained in heart and lungs of vaccinated group. The Antibodies reactive to ScGST appeared within four weeks of first dose and were able to neutralize the GST activity up to 86%. In an earlier study we have shown vaccine potential of ScGST against B. malayi by ADCC. Evaluation of cytokine profile in T-cells isolated from BALB/c mice immunized with ScGST were also showed predominance of Th2 response which further maintained the humoral immunity generated by ScGST administration in mice. The overall observations prompted us to envisage ScGST as a potential vaccine candidate against lymphatic filariasis.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="Anandharaman, V" sort="Anandharaman, V" uniqKey="Anandharaman V" first="V" last="Anandharaman">V. Anandharaman</name><name sortKey="Gupta, Sarika" sort="Gupta, Sarika" uniqKey="Gupta S" first="Sarika" last="Gupta">Sarika Gupta</name><name sortKey="Reddy, Maryada Venkatarami" sort="Reddy, Maryada Venkatarami" uniqKey="Reddy M" first="Maryada Venkatarami" last="Reddy">Maryada Venkatarami Reddy</name><name sortKey="Yadav, Marshleen" sort="Yadav, Marshleen" uniqKey="Yadav M" first="Marshleen" last="Yadav">Marshleen Yadav</name></noCountry><country name="Inde"><noRegion><name sortKey="Rathaur, Sushma" sort="Rathaur, Sushma" uniqKey="Rathaur S" first="Sushma" last="Rathaur">Sushma Rathaur</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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